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Hironobu Ihn Selected Research

Transforming Growth Factor beta (TGF-beta)

8/2009Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma.
2/2008Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis.
8/2006Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma.
9/2005Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts.
8/2005Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts.
4/2005Scleroderma, fibroblasts, signaling, and excessive extracellular matrix.
12/2002Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis.
11/2002Pathogenesis of fibrosis: role of TGF-beta and CTGF.
9/2002Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts.
1/2002The role of TGF-beta signaling in the pathogenesis of fibrosis in scleroderma.

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Hironobu Ihn Research Topics

Disease

44Systemic Scleroderma (Systemic Sclerosis)
12/2020 - 01/2002
43Neoplasms (Cancer)
01/2022 - 12/2007
40Melanoma (Melanoma, Malignant)
09/2021 - 04/2008
28Fibrosis (Cirrhosis)
12/2020 - 01/2002
15Psoriasis (Pustulosis Palmaris et Plantaris)
09/2020 - 09/2008
13Dermatomyositis (Dermatopolymyositis)
01/2019 - 07/2002
10Extramammary Paget Disease (Paget Disease, Extramammary)
01/2022 - 02/2015
10Hemangiosarcoma (Angiosarcoma)
10/2020 - 02/2015
9Neoplasm Metastasis (Metastasis)
07/2021 - 04/2008
7Inflammation (Inflammations)
09/2021 - 12/2011
7Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2020 - 12/2007
7Autoimmune Diseases (Autoimmune Disease)
05/2020 - 04/2012
7Localized Scleroderma (Morphea)
09/2013 - 06/2004
6Systemic Lupus Erythematosus (Libman-Sacks Disease)
08/2017 - 02/2003
5Disease Progression
08/2020 - 11/2013
5Collagen Diseases (Collagen Disease)
05/2020 - 09/2011
5Infections
05/2018 - 05/2011
4Pemphigus (Pemphigus Vulgaris)
01/2021 - 04/2009
4Psoriatic Arthritis
01/2021 - 04/2016
4Sclerosis
01/2020 - 07/2011
4Carcinogenesis
05/2019 - 12/2011
4Skin Diseases (Skin Disease)
01/2018 - 05/2006
4Cicatrix (Scar)
08/2017 - 09/2013
4Ulcer
08/2017 - 09/2013
3Skin Manifestations
05/2020 - 10/2004
3Xeroderma Pigmentosum (Kaposi's Disease)
12/2018 - 03/2008
3Myositis (Idiopathic Inflammatory Myopathies)
11/2018 - 10/2012
3Myasthenia Gravis
11/2018 - 07/2016
3Dermatofibrosarcoma
04/2018 - 10/2002
3Polymyositis
07/2016 - 08/2007
3Rheumatic Diseases (Rheumatism)
10/2015 - 07/2012
3Mixed Connective Tissue Disease (MCTD)
10/2015 - 02/2003
3Wounds and Injuries (Trauma)
01/2014 - 02/2002
2Disseminated Intravascular Coagulation
06/2020 - 11/2018
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2020 - 04/2015
2Erythema
01/2020 - 08/2017
2Onychomycosis (Tinea Unguium)
12/2019 - 10/2018
2Hypoxia (Hypoxemia)
02/2019 - 06/2014
2Skin Neoplasms (Skin Cancer)
12/2018 - 07/2017
2Carcinoma (Carcinomatosis)
12/2018 - 01/2008

Drug/Important Bio-Agent (IBA)

21Proteins (Proteins, Gene)FDA Link
07/2021 - 12/2003
19MicroRNAs (MicroRNA)IBA
01/2020 - 12/2010
18CollagenIBA
12/2020 - 10/2003
17Biomarkers (Surrogate Marker)IBA
06/2021 - 11/2013
15CytokinesIBA
02/2021 - 02/2004
13DNA (Deoxyribonucleic Acid)IBA
01/2022 - 10/2002
11NivolumabIBA
06/2020 - 01/2016
10AntigensIBA
02/2021 - 07/2002
10AntibodiesIBA
10/2020 - 07/2002
10Transforming Growth Factor beta (TGF-beta)IBA
08/2009 - 01/2002
9Immune Checkpoint InhibitorsIBA
09/2021 - 01/2016
9Messenger RNA (mRNA)IBA
01/2018 - 12/2010
8EnzymesIBA
07/2017 - 02/2003
7Bleomycin (Blenoxane)FDA LinkGeneric
12/2020 - 04/2013
7ImmunosorbentsIBA
09/2013 - 02/2003
6Transforming Growth Factors (Transforming Growth Factor)IBA
01/2018 - 01/2002
5AutoantibodiesIBA
08/2020 - 07/2002
5Adrenal Cortex Hormones (Corticosteroids)IBA
05/2018 - 10/2004
5Indicators and Reagents (Reagents)IBA
11/2017 - 02/2003
5Intravenous Immunoglobulins (IVIG)FDA Link
02/2017 - 01/2006
4Cell-Free Nucleic AcidsIBA
01/2022 - 09/2020
4Peptides (Polypeptides)IBA
02/2021 - 07/2004
4Collagen Type I (Type I Collagen)IBA
12/2020 - 02/2005
4LigandsIBA
05/2020 - 01/2016
4Infliximab (Remicade)FDA Link
01/2019 - 04/2016
4SteroidsIBA
02/2017 - 09/2008
4Tumor Biomarkers (Tumor Markers)IBA
01/2016 - 03/2011
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2021 - 01/2015
3Interleukin-17 (Interleukin 17)IBA
02/2021 - 01/2012
3Adalimumab (Humira)FDA Link
01/2021 - 05/2018
3Transcription Factors (Transcription Factor)IBA
11/2020 - 01/2016
3Prednisolone (Predate)FDA LinkGeneric
11/2020 - 04/2009
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2020 - 01/2014
3Docetaxel (Taxotere)FDA Link
01/2020 - 02/2015
3SolutionsIBA
10/2018 - 01/2016
3Interleukin-6 (Interleukin 6)IBA
09/2018 - 05/2017
3InterferonsIBA
05/2018 - 01/2014
3Itraconazole (Sporanox)FDA LinkGeneric
01/2018 - 05/2011
3HLA Antigens (Human Leukocyte Antigens)IBA
01/2017 - 07/2004
3Silver Sulfadiazine (SSD)FDA LinkGeneric
10/2015 - 09/2013
3Angiopoietin-Like Protein 2IBA
02/2014 - 12/2011
3Interleukin-13IBA
03/2011 - 10/2004
3RNA (Ribonucleic Acid)IBA
03/2009 - 02/2003
3Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
06/2003 - 09/2002
2ParaffinIBA
02/2021 - 04/2010
2Small Interfering RNA (siRNA)IBA
11/2020 - 01/2015
2cadherin 5IBA
10/2020 - 08/2014
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
09/2020 - 05/2006
2IpilimumabIBA
06/2020 - 12/2019
2C-Reactive ProteinIBA
01/2020 - 11/2018
2Anti-Bacterial Agents (Antibiotics)IBA
01/2019 - 11/2018
2pembrolizumabIBA
01/2019 - 01/2017
2Paclitaxel (Taxol)FDA LinkGeneric
01/2019 - 02/2015

Therapy/Procedure

31Therapeutics
07/2021 - 10/2004
11Immunotherapy
02/2021 - 04/2009
3Cell- and Tissue-Based Therapy (Cell Therapy)
05/2021 - 03/2016
3Drug Therapy (Chemotherapy)
04/2020 - 02/2015
3Combination Drug Therapy (Combination Chemotherapy)
01/2020 - 02/2015
3Skin Transplantation (Skin Grafting)
09/2016 - 04/2013
2Radiotherapy
05/2020 - 01/2019